PRODUCTION PLANNING FOR A WINERY WITH MIXED INTEGER PROGRAMMING MODEL

This paper presents a Mixed Integer Programming (MIP) model to wine production planning. In a MIP problem, some of the decision variables are constrained to have only integer values at the optimal solution. The use of integer variables greatly expands the scope of useful optimization problems. The purpose of this paper is to propose a concise formulation of the production planning problem oriented at the food industry and in particular to wine production. The main idea is the selection of new products to be produced and the determination of the quantity of them in order to maximize profit of a winery. This is a fixed-charge problem and in this paper branch and bound method is used to solve the problem. The results obtained from a MIP model indicate that the selection of new products can favorably produce optimal schedules

Shelf Layout With Integrating Data Mining And Multi-Dimensional Scaling

Thanks to information, communication and technological improvements in these days, data mining method are used to obtain significant results from very large data sets. In terms of businesses, decisionmaking in product design, placement, layout and so on issues are of vital importance. Association rules taking part in data mining topic is used so much especially in marketing research in the market basket. The Multi- Dimensional scaling (MDS) method is also frequently used for the positioning of products in the marketing field. MDS is measured similarities between products, units and so on according to the method of Euclidean space. Relations between products or units are visualized in two or three dimensions using MDS method according to the purpose. The aim of this study is to determine the product shelf layout using association rules according to the relationship map of the products generated by MDS. Together with the association rules (conviction ratios) used in data mining field, proximity coefficients between products were calculated and used in MDS analyze. Product groups were created by using MDS and proximity coefficient combinations made up between products. Shelf layout ensuring similar products in line with side by side was determined with the help of association rules. The applicability of the proposed method for products and alternative shelf layout was presented visually. 750 shopping and customers who purchase products in the same shelf made up the data of this study. In this study, placement of the products designed to maximize the benefit level for customers in terms of time and convenience

Clopidogrel versus ticagrelor in chronic kidney disease patients presenting with acute coronary syndrome: A retrospective evaluation

Aim: To compare the efficacy and bleeding risk of clopidogrel versus ticagrelor in patients presenting with the acute coronary syndrome (ACS). Method: This was a single-center retrospective comparison of in-hospital and 1-year major advance cardiovascular events (MACE) in patients with ACS and reduced estimated glomerular filtration rate (eGFR <60 mL/min) who were treated with clopidogrel or ticagrelor in addition to aspirin. Clinicodemographic features, medication use, and laboratory values were recorded. eGFR was calculated by means of the modification of diet in renal disease (MDRD) equation. The Killip classification was used to quantify the severity of heart failure. The primary outcome measures were in-hospital and 1-year MACEs and major and minor bleeding. MACE definition included recurrent myocardial infarction, stroke, and cardiovascular death. Results: In total, 235 patients (40.9% female, mean age 67.8 ± 12.4 years) were included. Of all patients, 56% presented with ST-elevation myocardial infarction (STEMI), whereas 44% had a non-ST-elevation myocardial infarction. Sixty-eight patients were treated with ticagrelor, while 167 patients were administered clopidogrel. The groups were comparable in terms of in-hospital mortality, cerebrovascular accident (CVA), and re-infarction rates. There was no statistical difference between the mortality, CVA and re-infarction rates between the groups at 12-month. In-hospital minor bleedings were more common among ticagrelor users. In-hospital major bleeding frequencies were similar in both groups. There was no statistical difference in terms of major or minor bleeding rates at 12 months. Conclusion: The findings of the present study showed comparable efficacy and bleeding risk in ACS patients who were treated clopidogrel or ticagrelor

Coronary thrombus in 34-year-old female patient with 4G/4G polymorphism in the PAI-1 gene

AbstractGenetic factors and hypofibrinolytic state may contribute to the likelihood of developing in myocardial infarction (MI) in young women rather than traditional risk factors. High plasminogen-activator inhibitor-1 (PAI-1) level and PAI-1 gene polymorphism have been shown to be associated with thrombotic events such as myocardial infarction, deep venous thrombosis, and stroke. We determined 4G/4G polymorphism in a 34-year-old female patient with subacute anterior myocardial infarction and coronary thrombus in left anterior descending artery on coronary angiogram

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks

Fuzzy TOPSIS method for academic member selection in engineering faculty

This paper presents fuzzy TOPSIS (technique for order preference by similarity to ideal solution) method for academic member selection. In academic member selection problem the ratings of various alternatives versus various subjective criteria and the weights of all criteria are assessed in linguistic variables represented by fuzzy numbers. Fuzzy numbers try to resolve the ambiguity of concepts that are associated with human being's judgments. To determine the order of the alternatives, closeness coefficient is defined by calculating the distances to the fuzzy positive ideal solution (FPIS) and fuzzy negative ideal solution (FNIS). Universities can select the appropriate academic member by using fuzzy TOPSIS method. By this way the quality of education will be increased in universities. © 2007 Springer

Gorlin syndrome with osteoma in the maxillary sinus (case report) Gorlin sendromu: Radyolojik bulgular.

Gorlin syndrome is a rare autosomal dominant disorder characterized by multiple basal cell carcinomas of the skin, odontogenic keratocysts of the jaw, various skeletal abnormalities, and lamellar falx calsifications. Many associated lesions have been reported. In this report, we present a case of Gorlin syndrome with an osteoma in the maxillary sinus which has never been reported in the literature

Spontaneous regression of basal ganglia lesions in a case of neurofibromatosis type 1 (case report) Nörofibromatozis tip 1 olgusunda bazal gangliyon lezyonlarinin spontan regresyonu.

Neurofibromatosis type 1 is characterized on magnetic resonance imaging by optic nerve gliomas, parenchymal gliomas, and foci of prolonged T2 relaxation involving the brainstem, cerebellum, midbrain, internal capsule, and basal ganglia. We report a child with neurofibromatosis type 1 in whom serial magnetic resonance imaging demonstrates spontaneous regression of basal ganglia lesions. These lesions, characterized on magnetic resonance imaging by increased signal intensity on T1- and T2-weighted sequences, involved the globus pallidus and internal capsules in a bilateral fashion

Periaortic abscess forming pulsatile sac around graft in a patient with prosthetic valve endocarditis after bentall operation

A 62-year-old man with high fever, general fatigue, and history of transient ischemic attack was transferred to our cardiology clinic with high clinic suspicious of endocarditis. He had a history of mitral ring annuloplasty and coronary artery bypass grafting operation before many years ago and reoperation for aortic dissection as Bentall procedure about 3 months ago. Blood tests showed leukocytosis with massive elevation of C-reactive protein, modest elevation of troponin, marked elevation of International Normalized Ratio, mild anemia, and hypoalbuminemia. Transesophageal echocardiogram (TEE) revealed a 4-mm × 15-mm round mobile mass originating from the anterior part of the mitral annular ring. In addition, there were a sac surrounding aortic graft and surrounding aneurismal aorta suggests a separation of graft because of possible aortic perivalvular abscess. There was blood flow into the sac and extensive thrombus with mobile component was seen in it. Blood cultures were positive for Streptococcus pneumoniae. Vancomycin, gentamicin, and rifampicin were chosen as antibiotic regimen. Early surgery planned for endocarditis and drained abscess cavity. However, the patient was persistently refused the third heart surgery operation. Repeat TEE showed the absence of vegetation on mitral valve and evident shrinkage of thrombus. Chest X-ray showed large left pleural effusion. Computed tomography with contrast enhancement confirmed this finding and revealed that contrast leak to the periaortic area and spreading a path under pulmonary artery to adjacent of the anterior wall of left ventricle. Thoracentesis was performed. Fistula to left pleura was suspected but not clearly confirmed. At 6 weeks of hospitalization, he clinically deteriorated. Due to confusional state, informed consent was obtained from attending relatives. The patient was transferred to the operating room. Cardiopulmonary resuscitation was initiated and thoracotomy was performed. Dehiscence of the aortic valve was seen. Infected tissues were extracted and repair with new prosthesis aortic valve was performed. Despite all resuscitation efforts, the patient died

The genetic variants of solute carrier family 11 member 2 gene and risk of developing type-2 diabetes

Type-2 diabetes (T2DM) is a metabolic disorder characterized by long-term insulin resistance, impaired insulin secretion from -cells, and loss of beta cell mass and function. Inflammation and oxidative stress play a key role in the development of diabetes and are associated with insulin resistance. Notably, recent studies have demonstrated an association between body iron stores, insulin resistance and T2DM. Free iron, a powerful pro-oxidant molecule, is involved in oxidative stress, lipid peroxidation and endothelial dysfunction via its ability to generate free radicals. Specifically, the accumulation of iron in beta cells triggers oxidative stress and DNA damage, which have been reported to be associated with -cell death and apoptosis. Solute carrier family-11 member-2 (SLC11A2) functions to transport ferrous iron and some divalent metal ions throughout the plasma membrane and across endosomal membranes. Functional polymorphisms in the SLC11A2 gene have been reported to cause excess storage of iron, resulting in iron overload. In this study, we evaluated the association between T2DM and SLC11A2 gene variants IVS4+44C/A, 1303C/A and 1254T/C by performing PCR-RFLP analysis on 100 T2DM patients and 100 healthy subjects. PCR products were digested with MnlI, MboI and SfanI restriction endonucleases and the products were then separated by 3% agarose gel electrophoresis. The genotype frequencies of the 1254T/C and 1303C/A SLC11A2 gene variants did not differ between healthy controls and T2DM patients (P>0.05). But, in recessive model (P=0.037) and homozygous CC genotype (P=0.030) for IVS4+44C/A showed significant correlation with T2DM risk. It is thought that presence of C allele of IVS4+44C/A plays pathological roles